The 10 Best Vet Clinics in South Carolina — 2026
We compared all 655 vet clinics in South Carolina on the data that matters: services offered, posted hours, and how easy each one is to reach. No pay-to-play — this ranking comes straight from the listings data, updated November 2026.
#1 · Banfield Pet HospitalGreer Spay & neuterVaccinationDentalEnd of life
Mon-Fri 7am-6pm, Sat 7:30am-5pm
#2 · Dutch Fork Animal HospitalIrmo Emergency
Mon–Fri 8:00 AM - 6:00 PM, Sat 8:00 AM - 4:00 PM
#3 · Haywood Road Animal HospitalGreenville EmergencySpay & neuterVaccinationDentalEnd of life
Monday - Friday: 7:30am - 5:30pm
#4 · Critter Care Wellness & Rehabilitation CenterSpartanburg Spay & neuterDental
Mon-Thurs: 8:00 AM-6:00 PM, Friday: 8:00 AM-3:00 PM
#5 · Platt Springs Road Animal ClinicWest Columbia EmergencyDental
Mon–Thu 8:00am–6:00pm
#6 · Midlands Veterinary PracticeColumbia Urgent careSpay & neuterVaccinationDental
Mon–Fri 7:30am–5:00pm, Sat 8:00am–12:00pm
#7 · Lake Murray Animal HospitalGilbert Spay & neuterDental
Mon-Fri 8:00 AM – 6:00 PM
#8 · Upstate Vet Emergency and Specialty CareGreenville EmergencySpecialist
Emergency Hours 8:00am - 2:00am
#9 · Twin Oaks Veterinary ClinicLandrum EmergencyUrgent careSpay & neuterDental
Monday – Friday 8:00 am – 5:00 pm
#10 · Crosswinds Animal HospitalGreenville DentalEnd of life
Mon, Thu, Fri 8:00 am - 1:00 pm, 2:30 pm-5:30 pm, Tue 8:00 am - 1:00 pm
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How we rank: every listing earns points for listed services
(emergency, 24-hour, urgent care, low-cost, spay & neuter, vaccination, mobile, cat clinic, equine, specialist, holistic, walk-in, dental, end of life),
posted hours, and working contact details. The ranking is recalculated with every data update.